Xinhuanet, Beijing, May 8 (Sun Hui) On May 7, the State Food and Drug Administration issued a notice that the State Food and Drug Administration organized the drafting of seven methods including "Inspection Methods for Hard Granules in Toothpaste", which was reviewed and approved by the Director's Meeting of the Technical Committee of the Cosmetic Standardization of the State Food and Drug Administration. It is now released and included in the corresponding chapter of the "Cosmetic Safety Technical Specifications (2015 Edition)". The new regulations will be implemented from March 1, 2026.

The seven methods are "Examination of hard particles in toothpaste", "Examination of diethylene glycol and ethylene glycol in toothpaste", "Examination of soluble and free fluorine in toothpaste", "Examination of total fluorine in toothpaste", and "Examination of in vitro skin allergic reaction ARE-Nrf2 luciferase LuSens test method". "Inspection Methods of 43 Elements such as Lithium in Cosmetics" and "Inspection Methods of 43 Elements such as Lithium in Toothpaste" are revisions to the inspection methods and replace the original inspection methods in "Cosmetic Safety Technical Specifications (2015 Edition)".

Among the above methods, five items are closely related to toothpaste. The "Examination Methods for Superhard Granules in Toothpaste" mentions that the superhard Granule Detector should be used as a testing instrument, and the slides should be used as a test material to replace the teeth for superhard Granule Inspection. The toothpaste sample should be rubbed back and forth under a certain pressure and frictional times to observe whether there are scratches on the slide.

"Testing Methods for Diethylene glycol and Ethylene Glycol in Toothpaste" mentioned that after the sample is extracted, it is separated by a gas chromatograph, detected by a hydrogen flame ionization detector, qualitatively qualitatively, peak area is quantified, and the content is calculated by the standard curve method.

The detection limits of diethylene glycol and ethylene glycol in this method are both 1.5 ng and the quantification limits are both 5 ng. When the sampling volume is 1 g, the detected concentrations are 37.5 mg/kg, and the minimum quantitative concentration is 125 mg/kg.

"Inspection Methods for Soluble and Free Fluorine in Toothpaste" mentions that after the fluoride in the toothpaste is dissolved and extracted by water, sodium fluoride, ammonium fluoride, stannous fluoride and olafluoride free fluoride ions; after the sodium monofluorophosphate is acid-treated, free fluoride ions can also be released, the solution potential value is measured with the fluoride ion selection electrode, and the content of soluble fluorine or free fluorine in the toothpaste is calculated through standard curves.

Toothpaste containing sodium monofluorophosphate in the product formula is suitable for soluble fluorine detection methods; soluoroform toothpaste containing sodium monofluorophosphate in the product formula is suitable for free fluorine detection methods. If the fluoride used exceeds the above fluoride, the applicability of the detection method will be discussed.

The "Inspection Method for Total Fluorine in Toothpaste" mentions that after the sample is derivatized and extracted, it is separated by gas chromatography and detected by hydrogen flame ionization detector. It is qualitative based on the retention time and the ratio of fluoride to the internal standard peak area is quantitative.

The detection limit for total fluorine of this method is 0.001 mg, and the lower limit for quantitative is 0.002 mg. When the sampling volume is 0.2 g, the detection concentration of this method is 5 mg/kg, and the minimum quantitative concentration is 10 mg/kg.

"The Test Method for 43 Elements of Lithium and Other In Toothpaste" mentions that after the sample is digested by acid into solution, it enters a high-temperature radio frequency plasma with argon as a matrix through a pneumatic atomizer in the form of an aerosol. After evaporation, dissociation, atomization, ionization and other processes, it is converted into positively charged positive ions and enters the mass spectrometer through the ion acquisition system. The mass spectrometer is separated according to the mass-charge ratio, and the mass spectrometer integrates the area of ​​the mass spectrometer is proportional to the number of ions entering the mass spectrometer. That is, the concentration of the element to be measured is proportional to the signal intensity CPS generated by each element, and is quantitatively compared with the standard series.

If 0.2g of the sample is taken and the volume is fixed to 50 mL, the concentration and minimum quantitative concentration are detected in this method.

[Editor in charge: Bai Bixuan]