From May 12 to 14, the 36th Medical Economic Information Release Conference, hosted by the Southern Medical Economic Research Institute of the State Administration of Drug Administration and hailed by the industry as the "barometer of the development of China's pharmaceutical industry", was held in Guangzhou. This conference is themed "Dream-building Full-Chain Innovation Cycle - Coordinated Development of Quality and Efficiency Improvement" and brings together academicians of the two academies and other experts and scholars, government and enterprise representatives to conduct in-depth discussions on issues such as drug regulatory policies, industry cutting-edge trends and high-quality development of the pharmaceutical industry. During the meeting, Zhang Yunling, director and deputy general manager of Yiling Pharmaceutical, introduced the latest scientific research results of the innovative Chinese medicine Bazi Bushen Capsules in his thematic report.

In the report, Zhang Yunling said that in order to create a brand and product with lasting vitality and gain recognition from home and abroad, it is necessary to keep pace with the times and promote the creative transformation and innovative development of traditional Chinese medicine theories. After long-term exploration, the academician and expert team of Yiling Pharmaceutical systematically constructed the theoretical system of network diseases for the first time, established a new discipline of Chinese medicine and established two major branches - "Meridian Theory" and "Qi Lian Theory". It is known as the fourth milestone in the history of the development of network diseases since the "Huangdi Neijing" laid the theoretical foundation for collateral diseases, Zhang Zhongjing of the Han Dynasty created the prescription for collaterals and the first development of collateral diseases in the Qing Dynasty, and Ye Tianshi of the Qing Dynasty enriched the treatment drugs for collateral diseases.

Based on the theory of Qi and meridians, the theory of essence, Qi is the driving force of life, and spirit is the embodiment of life", interprets key scientific issues such as life formation, life operation power, organ function, and spiritual thinking, and proposes the core pathogenesis of aging - deficiency of kidney essence is the foundation of aging, deficiency of vital energy is the key to aging, and loss of body and spirit is the manifestation of aging. It emphasizes that the longevity of life depends on the rise and fall of essence and spirit. The deficiency of essence and soul involves the five internal organs is the common pathogenesis of system aging and related diseases leading to the deficiency of kidney essence and essence and energy, and establishes the key path to nourish kidney essence, warm and nourish the body and spirit.

Zhang Yunling said that the Bazi Bushen Capsule, developed under the guidance of the Qilu theory, has been confirmed through a series of studies that it can intervene in the 10 major aging markers at the biological level through methods such as "reducing senescent cells", "maintaining mitochondrial homeostasis", and "maintaining stem cell vitality", and other methods to delay aging and prevent and treat aging-related diseases. This echoes and resonates with the theory of multi-mechanism interaction in the latest Western research.

In 2024, the international journal Phytomedicine published a paper titled "Randomized, double-blind, placebo-controlled, multicenter clinical study of Bazi Bushen Capsules for the treatment of premature aging." This clinical evidence-based study covering people aged 30-80 years old showed that after taking Bazi to nourish the kidney for 3 months, the activity of telomerase, the key aging indicator of telomerase, increased by 76.7%; at the same time, Bazi to nourish the kidney for 73% can effectively intervene in the aging process in neuropsychiatric, skin hair, skeletal muscle, genital reproduction and other aspects, and the aging symptoms closely related to the quality of life such as physical fatigue, waist and knee pain, forgetfulness and insomnia, etc. were improved.

A series of basic and mammalian studies have also confirmed the intervention characteristics of Bazi Bushen Capsules with multiple systems and multiple targets. In addition to delaying overall aging, Bazi Bushen Capsules have a systematic intervention effect on the function reduction of nine major systems including nerves, movement, circulation, breathing, digestion, immunity, reproduction, and skin, showing the unique advantages of traditional Chinese medicine in the field of anti-aging.

With the continuous growth of public health demand and the continuous expansion of the scale of the silver hair economy, anti-aging research has become a cutting-edge hot spot in the international biomedical field. Traditional Chinese medicine’s systematic intervention strategy for aging based on a holistic view shows unique clinical value and development potential. Zhang Yunling said that at present, Bazi Bushen Capsules have obtained registration approvals in eight countries including Canada and Thailand, and the latest scientific research results of traditional Chinese medicine anti-aging are entering thousands of households at home and abroad from the laboratory.

[Editor in charge: Wang Yuqi]